How to Obtain a Diagnostic Bone Marrow Sample From the Sternum of an Adult Horse

نویسنده

  • Debra C. Sellon
چکیده

Equine bone marrow analysis is an often underused technique that can provide invaluable diagnostic and prognostic information for horses with quantitative or qualitative abnormalities of blood cells. The primary function of bone marrow is the production of erythrocytes, leukocytes, and platelets. Consequently, abnormalities in the bone marrow are often reflected in the numbers or morphology of circulating blood cells. Conversely, systemic disease that alters the number or function of blood cells often results in compensatory changes in the bone marrow production of those cells. Abnormalities in the number or morphology of circulating erythrocytes, platelets, or leukocytes that cannot be adequately explained by consideration of history, physical examination, or routine laboratory testing are indications for bone marrow analysis. These indications include unexplained prolonged anemia, polycythemia, pancytopenia, leucocytosis, thrombocytopenia or thrombocytosis, or observation of atypical or neoplastic cells in the peripheral circulation (Table 1). Bone marrow analysis may also be included in the diagnostic plan for horses with chronic unexplained hypercalcemia or hyperproteinemia, which are laboratory abnormalities that are occasionally seen in horses with lymphosarcoma or multiple myeloma, respectively. Bone marrow aspirates and core biopsies are relatively easy to perform and are associated with minimal complications. Although bone marrow sampling is not often indicated in equine medicine, properly obtained samples can provide invaluable diagnostic and prognostic information that cannot be easily obtained in any other manner.

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تاریخ انتشار 2006